January 2016

1 Grant  $48,466 Awarded

Identification of Molecular Therapeutic Targets in Choroid Plexus using a Novel Mouse Model of Communicating Hydrocephalus

Amount: $50,000

Primary Investigator: Vuong, Shawn, MD, Goto, June, PhD, Mangano, Francesco, DO

Category: Communicating Hydrocephalus

  1. Examine whether the splicing mutation in Ccdc39 is indeed the causative mutation for HCP in the prh mice through genetic complementation tests;

  2. Examine whether the prh mutation results in increased CSF production in primary cultured CPECs; and

  3. Identify the developmental defects of choroid plexus in the prh mutant in immunohistochemistry and RNA-sequencing analysi


4 Grants  $180,897 awarded

Title: Monocytes in Intracerebral Hemorrhage

Amount: $35,941

Primary Investigators: Kyle B Walsh, MD and Mohamed S. Saleh, MD

Category: Intracerebral hemorrhage (ICH)

Investigation of monocyte subsets in peripheral blood and the brain hematoma in intracerebral hemorrhage (ICH)

Title: Mechanisms of Cortical Infarction Following Subarachnoid Clot Formation

Amount: $46,980

Primary Investigators: Jed Hartings, PhD and Chris Carroll, MD
Category: Brain Injury

Researchers will use diffusion-weighted (DW) and perfusion weighted (arterial spin labeling (ASL)) magnetic resonance imaging (MRI) to determine the spatial and temporal relationships of pathophysiologic events- cortical ischemia, SD, and cytotoxic edema – leading to infarction in the initial minutes and hours after SAH. They will also test interventional drug treatments (nimodipine and ketamine) to interfere with these mechanisms, gain further insight into causal sequence, and provide a translational therapeutic strategy to mitigate early brain injury in patients.

Title: Developing Objective Methods and Algorithms to Assess Movement: Ultimately Leading to the Replacement of the Subjective Movement Component of the UPDRS III

Amount: $47,976
Primary Investigators: George Mandybur, MD and Kevin Biddell, MD

Category: Parkinson’s Disease

The scope of this project is to develop patient motion protocols and corresponding algorithms to measure established motion patterns.

Title: Drug Screening for the Treatment of Diffuse Intrinsic Pontine Glioma and High-grade Glioma

Amount: $50,000

Primary Investigators: Jennifer Kosty, MD and Q. Richard Lu, PhD

Category: Pediatric glioma

There are currently no effective chemotherapies for the treatment of diffuse intrinsic pontine glioma and pediatric high grade glioma. The goal of this study is to screen a large library of small compounds to identify potential therapeutic agents and pathways for further research.


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