November 2009

3 Grants/$126,075 Awarded

Bilirubin Oxidation Products in Cerebral Vasospasm

Amount: $50,000
Primary Investigator: Mario Zuccarello, MD
Category: Cerebrovascular


Vasospasm, the sudden constricting of a blood vessel that often occcurs in the days following an aneurysm rupture and hemorrhage, can cause additional brain damage after the initial event. It is unclear as to how or why a vasospasm might occur, and so treatment remains elusive. Here, researchers are attempting to determine the cause of vasospasm at the molecular level. They will test a hypothesis that bilirubin, a waste product of the normal breakdown of red blood cells, could be an agent in constricting blood vessels and causing vasospasm. 

ECOG for Early Detection of Delayed Ischemia after aSAH

Amount:                     $50,000
Primary Investigator: Jed A. Hartings, PhD
Category: Cerebrovascular


Patients' neurological condition can continue to deteriorate after hospitalization for stroke or traumatic brain injury, but there are no methods to detect secondary injuries before the damage becomes permanent. This project monitors the brain activity of patients to investigate spreading and dangerous "tsunami-like waves" of brain cell inactivity that occurs in many patients for days after their primary injury. By providing this window into how the brain reacts to trauma, such monitoring may enable physicians to protect the brain from further damage. 

3T versus 1.5T MR Approaches in Target Definitions for Malignant Gliomas: Is There A Significant Difference in Tumor Extent and Radiation Treatment Volume?

Amount: $26,075
Primary Investigator: Christopher McPherson, MD
Category: Brain Tumor


To determine whether using a stronger magnet when performing diagnostic magnetic resonance imaging (MRI) for radiation treatment planning in brain tumor patients can improve the accuracy of targeting treatment, and thus improve its effectiveness.


May 2009
3 Grants/$97,497 Awarded

Neurovascular Research Start-up

Amount: $50,000
Primary Investigator: Mario Zuccarello, MD
Category: Cerebrovascular


To provide the necessary equipment to further develop a burgeoning neurovascular research program with the University of Cincinnati Department of Neurosurgery.  

Stenting and Agressive Medical Management for Preventing Recurrent Stroke (SAMMPRIS) Clinical Trial

Amount:                     $22,500
Primary Investigator: Andrew J. Ringer, MD
Category: Cerebrovascular


To allow participation in a large National Institutes of Health (NIH) clinical trial with the purpose of determing how to best treat symptomatic intracranial arterial stenosis, a condition in which arteries in the brain have narrowed with a build-up of plaque. Blood thinning medication is widely used to manage this condition, but this study aims to determine whether surgical procedures, including angioplasty and stenting, should be recommended for all patients. 

Pediatric Cerebral Concussion Clinical Trial

Amount: $24,997
Primary Investigator: Todd Allen Maugans, MD
Category: Traumatic Brain Injury


To study the effect of sports-related concussions on young children, a population never studied before and espeically vulnerable to brain injury. The desired end result is the development of an imaging-based screening tool created specifically for children, whose nervous systems are known to show more extensive symptoms and longer recovery periods after concussion. 

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